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Dexamethason is used as an anti-inflammatory medication. Dexamethason relieves inflammation in various parts of the body. It is used specifically to decrease swelling (edema), associated with tumors of the spine and brain, and to treat eye inflammation.
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Dexamethasone taken with ciprofloxacin at 1 mg/kg and 3.5 increased liver enzymes (aspartate aminotransferase, AST and ALT, GGT, lactate dehydrogenase, ALP) after 7 days. At the highest dose (3.5 mg/kg), maximum effect was not reached. Ciprofloxacin is currently used as a first line or third treatment for uncomplicated cystitis or prostatitis in adults as first line therapy for prostatitis in children. It should be used with caution in patients impaired liver function or with known chronic renal loss. Ciprofloxacin should not be used in patients receiving chemotherapy. Caution should be used when Ciprofloxacin is administered to patients with history of serious hypersensitivity (e.g. Stevens-Hurt syndrome) or to patients receiving concomitant Diflucan over the counter in australia drugs (e.g. rifampin, ketoconazole, terfenadine). This drug should be used cautiously in patients with hepatic disease or in patients with impaired kidney function (e.g. potassium balance, reduced urinary output, severe renal impairment) (see ADVERSE REACTIONS (6.2), CLINICAL PHARMACOLOGY (12.2). The use of Ciprofloxacin with daptomycin has been reported to produce anemia. Patients receiving drug combinations should be advised of this potential increased risk. In one controlled clinical trial with patients chronic kidney disease and Ciprofloxacin in the treatment of cysts, incidence acute kidney injury was reduced at 1 week and 7 days when the drug combination was used as an adjunctive therapy (N=21), but was increased compared with placebo (P<0.05). In a clinical trial of chronic nonalcoholic steatohepatitis (N=40) treated with Ciprofloxacin 500 mg/day and celecoxib 150 the incidence of acute renal failure was increased (P<0.1) compared with Ciprofloxacin 250 mg/day (N=40) and Celecoxib 75 therapy when compared with placebo (N=38), concomitant use of fluconazole and rifampin (P=0.02; N=39). In a clinical trial with patients chronic renal failure and Ciprofloxacin 500 mg/day celecoxib (150 mg/day) in the treatment of prostatitis, Ciprofloxacin resulted in a significant reduction urine ammonia levels (P<0.001), and the incidence of acute renal failure was decreased and the incidence of elevated serum bilirubin and proteinuria was decreased (P<0.001). When ciprofloxacin is administered to patients with a history of hypersensitivity to its constituents or an inadequate response to existing medication, anaphylaxis may occur. The patient should be closely observed and the drug discontinued in these patients unless there is definite and improvement in symptoms. The use of a nonsteroidal anti-inflammatory drug (NSAID), such as aspirin or ketorolac, should be considered in patients with anaphylactic reaction to other anodynes. This is a recognized adverse effect of this drug and usually does not require treatment. Aspirin or ketorolac may be useful to increase clearance of Ciprofloxacin since it is also able to inhibit the formation of prostaglandins. Ciprofloxacin can occasionally increase the risk for hyperkalemia. It should be noted that in this patient population, one-half of the patients had a prior history of hypersensitivity and 1.5% had an abnormal liver function test. Although it may be possible to develop hypersensitivity ciprofloxacin, the overall incidence of reactions is unknown. There has been only one case of hypersensitivity involving Ciprofloxacin in a patient who has prior history of hypersensitivity, and this adverse event was considered to be unrelated. There have been no reports of hypersensitivity reactions during the use of this medication. Patients who are receiving any other NSAID, including aspirin, should be treated with caution and monitored closely for increased intestinal permeability (see CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, DOSAGE ADMINISTRATION, DRUG INTERACTIONS) for at least 2 weeks and if indicated, change the NSAID. This medication can be used with all medications and is not compatible with any other NSAID. Adverse reactions related to concomitant use of theophylline, an antihistamine, with Ciprofloxacin.
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